PTHrP (1–34) treatment partially rescued both the total and phosphorylated FAK levels, suggesting that PTHrP may regulate FAK expression and activation.49 In human colon cancer cell lines (Caco-2 and HCT116), exogenous PTHrP upregulated FAK via the ERK/RSK pathway, rather than the p38 MAPK pathway, thereby promoting cell migration.50 Here, PTHLH is linked to malignant colon neoplasm.