Wang et al. [157] investigated arsenic trioxide against liver CSCs and reported that the induction of DNA demethylation after arsenic trioxide treatment activated microRNA-148a, leading to the inhibition of the NF-κB pathway and CSC properties in the multidrug-resistant HCC cell line MDR Bel-7402 and the resensitization of these cells to the drug 5-fluorouracil. This evidence concerns the gene NFKB1 and hepatocellular carcinoma.