APC and gastric cancer: GSPT1-238aa, encoded by circGSPT1, is expressed at low levels in GC tissues and suppresses carcinogenesis by inhibiting autophagy [37], while circAXIN1, which is highly expressed circRNA in GC cells, encodes the oncogenic protein AXIN1-295aa, which competitively binds to APC to enhance Wnt signaling activity [25].