The direct regulation of PLUM expression by NF-κB/p52 was further confirmed by CRISPR-mediated KD of NF-κB/p52 in two NF-κB mutant multiple myeloma cell lines (MMCLs), KMS11 and LP1, which resulted in the downregulation of PLUM expression (Supplementary Fig. 1a, b). This evidence concerns the gene LINC02362 and plasma cell myeloma.