Additionally, s-ASO-g11 and s-ASO-g12 treated cells showed diminished activity of pIRE1α-sXBP1 and EIF2α axis of UPR pathway regulation (Supplementary Fig. 7e), implying the importance of PLUM-EZH2 interaction in driving chemoresistance in MM through UPR activation. This evidence concerns the gene EZH2 and Miyoshi myopathy.