At the cell subtype level, MHC class II genes were upregulated in mregDC high samples across various tumor programs, including HLA-DRB1, HLA-DPA1, HLA-DPB1 and HLA-DMA in the respiration program, HLA-DMA in cell cycle G2/M program, HLA-DPA1 and HLA-DRA in cell cycle HMG-rich program, and HLA-DRA and HLA-DPA1 in the stress program (Supplementary Fig. 13B and Supplementary Data 13), indicating the immunogenic potential of these tumor programs in mregDC high samples. The gene discussed is HLA-DRB1; the disease is neoplasm.