Furthermore, our characterization of mregDCs using scRNA-seq and snATAC-seq data indicates their potential origin from cDC1, driven by intrinsic TFs like IRF8, and extrinsic factors such as pro-inflammatory cytokines (IL1β, TNFα, IL12, etc.), along with ECM genes from specific tumor cells and fibroblasts. This evidence concerns the gene IRF8 and neoplasm.