Human TZAP/ZBTB48 had been proposed to be a transcriptional activator of a small set of target genes, including Mitochondrial Fission Process 1 (MTFP1)26 and Zbtb48 knockout mice show a variety of phenotypes, including abnormal bone structure and eye morphology defects in young adults, and impaired glucose tolerance and behavioral deficits at late adult stages51, but the underlying mechanisms have not been studied. This evidence concerns the gene ZBTB48 and Impaired glucose tolerance.