In several diseases ANXA2 expression was higher in patients with nephrotic versus sub-nephrotic range proteinuria, including lupus nephritis (7.917 versus 6.049, p = 0.0078), IgA nephropathy (4.770 versus 3.885, p = 00079), FSGS (2.081 versus 1.012, p = 0.0146), and membranous nephropathy (2.118 versus 0.7312, p = 0.0293). Here, ANXA2 is linked to focal segmental glomerulosclerosis.