Among them, several genes have significant effects on the survival prognosis and TMN stage of COAD, such as NTN5, PPP1R1A, EFHD1, EME1, GLDN, CYP4F12, C1R1.AS1, VWCE, TRPM5, and TLR6. This evidence concerns the gene EME1 and colon adenocarcinoma.