DO analysis found that a total of 48 HS component target genes were enriched in CRC diseases, including PTGS2, DPP4, MAPK14, GSK3B, ACHE, CCND1, TNF, BAX, BCL2, CASP3, CASP8, etc. GO analysis showed that the target genes of HS components were mainly enriched in xenobiotic stimulus and lipopolysaccharide reaction. This evidence concerns the gene CASP3 and colorectal carcinoma.