Among them, several genes have significant effects on the survival prognosis and TMN stage of COAD, such as NTN5, PPP1R1A, EFHD1, EME1, GLDN, CYP4F12, C1R1.AS1, VWCE, TRPM5, and TLR6. The gene discussed is TLR6; the disease is colon adenocarcinoma.