Among them, several genes have significant effects on the survival prognosis and TMN stage of COAD, such as NTN5, PPP1R1A, EFHD1, EME1, GLDN, CYP4F12, C1R1.AS1, VWCE, TRPM5, and TLR6. Here, EFHD1 is linked to colon adenocarcinoma.