In patients with DO coincident with benign prostate hyperplasia and several animal models of DO induced through stricture of the urethra causing partial bladder outlet obstruction, studies observe decreased outward BK channel currents at rest and following detrusor contraction, decreased BKα mRNA and protein expression, and changes to β1 and β4 expression (Aydin et al. 2012; Chang et al. 2010; Hristov et al. 2013; Jiang et al. 2005; Kita et al. 2010; Li et al. 2008; Zheng et al. 2020). This evidence concerns the gene KCNMA1 and benign prostatic hyperplasia.