Severe cases are rare; however, both EGFR antibodies (cetuximab, 17% [36]; panitumumab, 16–33% [36, 44]) and TKIs (gefitinib, 15.6–63% [48–50, 52, 55, 56]; erlotinib, 10–42% [57, 58, 60]; afatinib, 10.9–23% [55, 62, 64, 65]; osimertinib, 12–18% [66–70]; dacomitinib, 10–20.7% [54, 56, 57]) can cause mild pruritus. The gene discussed is EGFR; the disease is Pruritus.