S100A6 and Hypertension resistant to conventional therapy: BP changes were similar in pre-specified subgroups, suggesting an important role for dysregulated aldosterone in the pathophysiology of both uncontrolled and resistant hypertension, and potentially a broader population of hypertensive patients.5 Though not subject to hypothesis testing, we noted reduced aldosterone and increased PRA levels that might suggest that baxdrostat may induce further urine sodium excretion in patients already treated with diuretics.