LRP1 and Sepsis: In a model of sepsis‐induced cardiac dysfunction (SIMD), hepAGT is primarily taken up by cardiac fibroblasts through low‐density lipoprotein receptor‐related protein 1 (LRP1), thereby mediating the development of SIMD.[45] Interestingly, we have also identified a similar “liver‐heart crosstalk” mechanism in the HFpEF model.