The phenomenon of exogenous AGT internalization mediated by LRP2 has previously been validated mainly in renal diseases, where it primarily occurs in renal proximal tubule cells.[79, 80, 81] However, the current study demonstrates that this phenomenon also exists in cardiac microvascular endothelial cells and participates in the regulation of HFpEF by inhibiting angiogenic signaling pathways. Here, LRP2 is linked to kidney disorder.