Pim3 is widely expressed in various tumor cells and endothelial cells, exerting pro‐angiogenic effects, and ultimately promoting the development of tumors.[42, 43] Based on these findings, we hypothesized that hepatic AGT mediated Pim3 expression in cardiac endothelial cells may be one of the key pathways to regulate HFpEF. This evidence concerns the gene AGT and neoplasm.