Recent studies have shown that it enhances the efficacy of colorectal cancer immunotherapy by promoting CD8+ and CD4+ T cell infiltration into tumor sites.82 In addition, this bacterium was shown to provide anti-inflammatory properties by preventing acute experimental colitis in mice through the induction of the immunoregulatory cytokine IL-10 and to limit the colonization of pathogenic bacteria in the gut.47,83. This evidence concerns the gene CD4 and colitis.