The study found that the bacterium degrades sugars on immunoglobulin A (IgA) in the intestinal mucus, and these deglycosylated immunoglobulins can reenter the bloodstream, where they are mistaken as foreign by the immune system.64 This triggers antibody sequestration, leading to IgA accumulation in the kidneys and resulting in renal insufficiency.64 Thus, both a deficiency and an overabundance of A. muciniphila in the gut might be detrimental and associated with disease development. This evidence concerns the gene CD79A and Renal insufficiency.