SELP and neoplasm: Vogt et al., developed a synthetic Notch (synNotch) receptor that selectively expresses an anti‐GD2‐CAR (Neuroblastoma antigen) upon binding to P‐selectin, a cell adhesion protein overexpressed in tumor new blood vessels.[44] These cells induced a significant reduction of tumor volume and survival over 21 days in a neuroblastoma mouse model, highlighting the antitumoral potential of TME‐based sensors (Figure 2CIII).