Therefore, the upregulation of the engaged gene PARP, APEX, polδ, DSS1, BLM and Mus81 and TDG in B cells indicate that the intervention of various blends, except for Blend 2, may enhance the correction of error‐prone processes at the Ig loci in B cell (both native and memory) to reduce the risk of B‐cell lymphomas, and to support the Ig class switch. Here, BLM is linked to B-cell non-Hodgkin lymphoma.