2019). In animal experiments, numerous studies using a high‐fat diet (HFD) (60% calories from fat) to induce obesity and metabolic diseases in mice have revealed the anti‐obesity effects of natural bioactive compounds. For instance, natural products such as capsaicin, anthocyanin, and resveratrol have been shown to ameliorate HFD‐induced obesity by improving lipid metabolism and insulin sensitivity, reducing adipose tissue expansion and inflammation, and regulating appetite and satiety (Li et al. 2020; Esposito et al. 2015; Wang et al. 2020). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.