The first noted model of idiopathic-like scoliosis was a tissue-specific knockout of adhesion G protein-coupled receptor G6 (Adgrg6; previously known as Gpr126), orthologous to a gene linked to human AIS (Karner et al., 2015; Kou et al., 2013). This evidence concerns the gene ADGRG6 and androgen insensitivity syndrome.