CRS patients that met the EPOS definition of type 2 inflammation (BEC ≥ 150 cells/μL or serum total IgE ≥ 100 IU/mL), showed increased SNOT‐22 scores (p = 0.04), VAS loss of smell scores (p = 0.03), VAS nasal blockage scores (p = 0.008) and VAS runny nose scores (p = 0.005) compared to patients that did not meet this definition (Figure S2). Here, IGHE is linked to congenital rubella syndrome.