IGHE and congenital rubella syndrome: CRS patients with increased BEC, ≥ 150 cells/μL or ≥ 250 cells/μL, showed increased VAS impact on daily life activities (p = 0.03; p = 004), whereas patients with increased serum total IgE or with comorbid asthma did not show differences in VAS impact on daily life activities compared to patients with serum total IgE < 100 IU/mL or without comorbid asthma (p = 0.88 and p = 0.47; Figure 5).