IGHE and chronic rhinosinusitis with nasal polyps: In this regard, it has been reported before that type 2 inflammation represents the predominant endotype of uncontrolled CRSwNP, characterized by a significantly elevated presence of mast cells, eosinophils and basophils, as well as high levels of IgE, Th2 cells, and type 2 cytokines (IL‐4, IL‐5, and IL‐13) in Western countries [10, 11].