Notably, for the aforementioned tumour‐prone clusters (Figure 3) whether derived from WT or KO samples, these cells demonstrate a notable augmentation in the RPG scores and increased potential for differentiation (Figure S25A), suggesting that the expression levels of specific RPGs could serve as quantitative indicators of tumour susceptibility for various lineages under p53 inactivation. This evidence concerns the gene TP53 and neoplasm.