Notably, both Atg7ΔCD4 mice that induced by TNBS rectal administration and Atg7ΔCD4CD45RBhighCD4+ T cell‐reconstituted Rag1−/− mice, displayed more severe colitis, suggesting that Atg7 deficiency disrupts Th1/Treg cell‐mediated mucosal immunity. This evidence concerns the gene ATG7 and colitis.