To elucidate the influence of Atg7 in CD4+ T cell immune responses of mucosal and colitis development, we generated Atg7 gene CD4+ T cell‐specific knockout mice (Atg7ΔCD4 mice) and examined the role of Atg7 on regulating differentiation of CD4+ T cell during colitis. This evidence concerns the gene ATG7 and colitis.