STING1 and neoplasm: Key successes include: (1) Profound reprogramming of immunosuppressive tumor microenvironments through macrophage polarization and STING pathway activation; (2) Synergistic induction of systemic antitumor immunity when combined with checkpoint inhibitors, achieving complete regression in refractory tumors; (3) Effective metastasis suppression via magnetically targeted immunotherapeutic delivery; and (4) Significant extension of survival across multiple aggressive tumor models through engineered biohybrid platforms.