In cerebral ischemia studies, activating TREK-1 by arachidonic acid (AA) could maintain sufficient electrochemical gradients to drive the glutamate uptake function of GLT-1 [88, 89], while inhibiting of TREK-1 activity with quinine could suppress the uptake of glutamate by astrocytes under hypoxia conditions [89]. This evidence concerns the gene KCNK2 and brain ischemia.