HIF1A and acute respiratory distress syndrome: The down-regulation of HIF-1α can reduce various organ dysfunctions caused by sepsis, as well as treat or alleviate sepsis through anti-inflammation, inhibition of glycolysis, and promotion of vasodilatation, and improve ARDS by reducing apoptosis and oxidative stress, decreasing inflammatory cytokines, and promoting epithelial cell as well as vascular repair.