As shown in Supplementary Fig. 22a, b and Supplementary Table 4, the tyrosine-phosphorylated FAK/SFK/ACLY and ALDOA axes were positively correlated with MCM3, MCM4, MCM5, MCM6, MCM7, CDC45, CCND1, CCNE1, CDK7, and CDK9 in ESCC tumor tissues. Here, MCM4 is linked to esophageal squamous cell carcinoma.