ACLY and neoplasm: Previous studies have confirmed that serine/threonine phosphorylation of metabolic molecules can increase the metabolic rate and facilitate malignant tumor progression, indicating that phosphorylation is critical for the activation of metabolic enzymes and the enhancement of tumor cell metabolism.42,43,53,54 Similarly, we reported that FAK and SFKs mediate the tyrosine phosphorylation of ALDOA and ACLY, thereby increasing the activity of these metabolic enzymes.