ALDOA and esophageal squamous cell carcinoma: As shown in Fig. 3a‒d and Supplementary Figs. 3a‒d and 4a, b the inhibition of FAK/SFKs effectively blocked the activity of ACLY and ALDOA and the production of OAA, G3P, and pyruvate (an active metabolite in the OAA and G3P pathways) in both primary and metastatic ESCC cells.