ACLY (the initiator of fatty acid synthesis) and ALDOA (a critical enzyme for glycolysis and gluconeogenesis) are located at the central linkage of glycolysis and glucose and lipid metabolism.40,41 Previous studies have demonstrated that the phosphorylation of serine/threonine residues in metabolic molecules can effectively transduce intracellular signals to mediate several malignant phenotypes of tumor cells.42,43 With the development of detection technologies, novel tyrosine phosphorylation sites and their relevant functions have received attention from researchers. Here, ACLY is linked to neoplasm.