As shown in Supplementary Fig. 22a, b and Supplementary Table 4, the tyrosine-phosphorylated FAK/SFK/ACLY and ALDOA axes were positively correlated with MCM3, MCM4, MCM5, MCM6, MCM7, CDC45, CCND1, CCNE1, CDK7, and CDK9 in ESCC tumor tissues. The gene discussed is CDC45; the disease is neoplasm.