Quercetagitrin (25 μM) effectively inhibited the growth and invasion of primary and metastatic KYSE410 and KYSE510 cells but did not further inhibit the malignant progression of these ESCC cells harboring ALDOA Y174A, Y302A, or Y328A mutants (Fig. 6e, f). The gene discussed is ALDOA; the disease is esophageal squamous cell carcinoma.