In general, physical activity has pleiotropic effects on vascular health.355–359 It reduces chronic low-grade systemic inflammation, cellular senescence, ET-1 signaling, TGF-β activity, and endothelial dysfunction and has a positive influence on several risk/modulating factors (e.g., hypertension and obesity).14,360–365. This evidence concerns the gene EDN1 and endothelial dysfunction.