POMC and hypertensive disorder: There were no significant differences between ACTH and corticosteroids regarding hypertension, with low heterogeneity, consistent with the findings of Chang et al. (OR: 1.19; 95% CI: 0.45–3.15; I2 = 0%).13However, the present study identified a higher tendency toward hypertension in the ACTH (28 patients) compared with the corticosteroid group (12 patients), diverging from previous literature.