POMC and Werner syndrome: Corticosteroid therapies included prednisolone, methylprednisolone, and dexamethasone, while ACTH was administered in various dosing regimens and tetracosactide, an analog of the natural hormone, was used for comparison.11The inclusion criteria across studies focused on children diagnosed with WS, confirmed through clinical and EEG findings, while exclusion criteria varied, often involving comorbid conditions such as tuberous sclerosis, prior steroid exposure, or significant organ dysfunction.