Additionally, there was no significant improvement on irritability (RR: 0.78; 95% CI: 0.30–1.99; I2 = 77%, or infection rates (RR: 0.69; 95% CI: 0.19–2.50;p = 0.57; I2 = 56%) in patients treated with ACTH compared with the corticosteroid group, as shown inFigure 3A–D. Here, POMC is linked to infection.