Cohort studies of leucine-rich glioma-inactivated 1 (LGI1) AE and N-methyl-D-aspartate receptor (NMDAR) AE have demonstrated poor correlation between mRS and impairments such as cognition, fatigue, and mood [7, 11] As an illustrative example, de Bruijn et al. [12] studied a sample of paediatric patients with anti-NMDAR encephalitis, and found deficits in attention, verbal memory, language, and executive function, as well as poor quality of life and significant fatigue despite good disease outcome, as measured by the mRS or Paediatric Cerebral Performance Category scale. Here, LGI1 is linked to viral encephalitis.