In addition, phosphatidylcholine species (PC) shifted from long chain poly-unsaturated PC species to shorter mono-unsaturated PCs (Fig. 1D) without overall change of summed PCs, which agrees with a recent study where a set of serum lipids including PC species allowed for a better prediction of PD progression/outcome than age, sex and risk gene LRRK2 mutation status45. This evidence concerns the gene LRRK2 and Parkinson disease.