Considering that the most frequent loss-of-function mutation, GBA1 N370S, that causes Gaucher disease confers resistance to tuberculosis in a zebrafish model120 it is tempting to speculate that GlcCer-mediated Mincle/Clec4e activation is protective against pathogens but possibly harmful if it sustains a microglial attack of neurons. The gene discussed is GBA1; the disease is tuberculosis.