Both, GlcCer and GlcSph accumulate in brain and peripheral organs in Gaucher disease90, but GlcSph are preferred as “biomarkers” in Gaucher disease91 because GBA1 deficient macrophages (Gaucher cells) were reported to accumulate predominantly the lyso-glycosphingolipid92, which however does not confer more or less toxicity to the acylated or deacylated version for neurons in the context of neuronal type Gaucher disease and PD, but might explain why GlcSph has gained more attention93–95 and is analyzed for newborn Gaucher screening96,97. This evidence concerns the gene GBA1 and Gaucher disease.