DDX3X and lung cancer: Furthermore, the levels of malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), both markers of oxidative stress-induced lipid peroxidation and ferroptosis, were significantly elevated in shDDX3X cells (Fig. 2K, L, Fig. S3M, N), indicating that DDX3X ablation instigates ferroptotic cell death in lung cancer cells.