Subsequently, by introducing p53fl/fl allele, we obtained KrasG12D;Ddx3xfl/flp53fl/fl (termed KP;Ddx3xfl/fl hereafter), KP;Ddx3xfl/+ and KP;Ddx3xfl/y mice, similarly, our data showed that depletion of Ddx3x also prolonged survival of mice bearing lung cancer dramatically (Fig. 1A), such survival benefit was also evident in KP;Ddx3xfl/+ mice when only a single Ddx3x gene copy was eliminated (Fig. S1D). Here, DDX3X is linked to lung carcinoma.