KRAS and lung cancer: Consequently, the mean synergy scores of adavosertib combined with sotorasib were all greater than 10, and most CI values were less than 1 for the six KRAS G12C mutant lung cancer cell lines, indicating a synergistic effect in both sotorasib-sensitive H358 and sotorasib-resistant H2122, H23, H2030, Calu-1, and SW1573 cell lines (Fig. 1A, B).