F2 and glioblastoma: Analyzing coagulation markers in the plasma of GBM patients (Fig. 2B) revealed that FII (prothrombin) activity, a critical factor in thrombin generation and clot formation, as well as FXIII, which is essential for fibrin clot stabilization, were significantly reduced (p ​< ​0.01 and p ​< ​0.05 vs. ctrl, Fig. 2B).