Classical clotting assays using pooled normal plasma identified that EVs from GBM patients exhibited significantly prolonged clotting times after 24 ​h of TTFields exposure (p ​< ​0.05 vs. control, Fig. 3D and E), accompanied by a significant reduction in TF levels (p ​< ​0.05 vs. control). This evidence concerns the gene TF and glioblastoma.