TMEM43 and Arrhythmogenic right ventricular dysplasia: A missense mutation, S358L, in TMEM43 is linked to the development of arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5) (8), a highly penetrant and lethal type with right ventricular dilation, fibro-fatty replacement of cardiomyocytes, heart failure, and early death (9).