In the well-established KC (K-rasLSL.G12D/+; Pdx-1-Cre) mouse model of pancreatic cancer, a pancreas-specific deletion of ST6Gal1 delayed tumor formation and accompanying fibrosis, indicating a strong tumor-promoting role for this enzyme and for N-linked α2–6 sialic acids (29). The gene discussed is CALCA; the disease is neoplasm.