Sialyl-Tn expression on MUC16 enhances the aggressive phenotype of pancreatic ductal adenocarcinoma (PDAC) tumor cells, increasing epidermal growth factor receptor (EGFR) interactions and triggering AKT and glycogen synthase kinase-3β oncogenic signaling (34). The gene discussed is EGFR; the disease is pancreatic ductal adenocarcinoma.