Consistent with the effect of LbNOX overexpression, both treatments restored the NAD+/NADH ratio to control levels (Fig. S5, K–M, O–Q) and partially rescued the proliferation impairment (Fig. 4, G–L).To further investigate the role of BDH1 in tumor growth, we subcutaneously injected PaTu-8988t cells with or without BDH1 knockdown into mice. Here, BDH1 is linked to neoplasm.