Additionally, RCC tumor cells exhibited universal and elevated expression of NK cell-activating ligands, including MHC class I chain-related protein A and B (MICA/B) and UL16-binding proteins (ULBPs) (ligands for NKG2D), as well as CD112 and CD155 (ligands for DNAM-1) (Figures 1G and 1H). This evidence concerns the gene CD226 and renal cell carcinoma.