Consistent with the effects of IFN-γ neutralization (Fig. 2), infected Ifngr1−/−Nlrc4−/−Casp11−/− mice experienced greater weight loss burdens than IFN-γ-sufficient Nlrc4−/−Casp11−/− animals 48h after infection (Fig. 3A–B). The gene discussed is NLRC4; the disease is infection.