Strikingly, all Ifngr1−/−Nlrc4−/−Casp11−/− mice reached predefined humane endpoints (e.g., <75% starting body weight, severe signs of morbidity) 72h post-infection, while all Nlrc4−/−Casp11−/− mice survived and regained their initial weight. The gene discussed is IFNGR1; the disease is infection.