More specifically, 53 genes were associated with the “obesity-related traits” term (P = 6.09 × 10−11; adjusted P = 2.69 × 10−7) in the iHS analysis, including MC4R in South Bangladeshi river buffalo, mutations of which are the commonest form of monogenic obesity in humans [56]. The gene discussed is MC4R; the disease is obesity due to melanocortin 4 receptor deficiency.