RBFOX1 and heart failure: Interestingly, RBFOX1 overexpression prevented the development of pathological hypertrophy induced by pressure overload (Figure 3C, left), thus positing that RBFOX1 regulation of splicing is a driver of pathological cardiac hypertrophy.70 In zebrafish, rbfox1 depletion caused a reduction in ventricular contractility and progressive heart failure, exemplifying the importance of RBFOX1 in cardiac contractility.111