Similarly, white blood cell count and cytokine levels, including IL-1β, IL-5, IL-6, IL-10, TNFα, interferon (IFN)γ, Monocyte Chemoattractant Protein (MCP)-1, and eotaxin (CCL11) were prospectively and longitudinally assessed throughout the course of CS (50% were AMI-CS) to characterize the acute inflammatory response in this context. The gene discussed is TNF; the disease is Cowden syndrome 1.