Moreover, in the rare cases where identical pathogenic SCN2A variants have occurred in different people, the patients still have distinct symptom profiles16, 21, 24, 67—for instance, the p.L1650P variant presented in a male child as episodic ataxia but in the father as episodic hemiplegia.67 This evidence concerns the gene SCN2A and Familial paroxysmal ataxia.