Similar genomic landscapes and active Bcl3 transcription were also observed in other cancer cell lines, including lung adenocarcinoma (A549), lymphoblastoid (GM12878), and colorectal carcinoma (HCT-116), suggesting a shared regulatory mechanism governing Bcl3 expression across diverse cancer types (Supplementary Fig. S1B). The gene discussed is BCL3; the disease is colorectal carcinoma.