MTO1 and hypertrophic cardiomyopathy: This MnmG-specific motif seems to be a hot-spot for disease mutations in MTO1, with the R313Q and K321N mutations (corresponding to EcMnmG residues R275 and K283, respectively) found implicated in hypertrophic cardiomyopathy [56, 58, 59] (see Supplementary Table S2 and Supplementary Fig. S9 for an overview and mapping on the α2β2 structure of the currently described disease mutations).