VIM and lung cancer: For example, S‐glutathionylation impedes filament elongation,[8] while PIAS1‐mediated SUMOylation enhances cell migration.[11] Recent studies have revealed that PRMT5‐mediated symmetric dimethylarginine (sDMA) regulates vimentin stability in MTAP‐deficient lung cancer.[13] In this study, we identified a novel regulatory mechanism involving PRMT1‐dependent asymmetric dimethylation (aDMA) at previously uncharacterized arginine residue within vimentin.