These LM2 cells, a subline established via serial in vivo selection from parental MDA‐MB‐231 breast cancer cells, exhibit significantly augmented metastatic tropism to pulmonary tissues relative to their progenitor counterparts.[32] Longitudinal bioluminescence imaging (BLI) monitoring revealed a significant reduction in metastatic colonization following vimentin depletion (Figure S1I,J, Supporting Information). Here, VIM is linked to breast carcinoma.