IL‐10, a cytokine secreted by various immune cells, including macrophages, plays a central role in immune regulation.[42] Furthermore, TAM‐derived IL‐10 has been shown to promote tumor progression through multiple mechanisms.[54] Interestingly, IL‐20, another member of the IL‐10 superfamily, has been previously reported to inhibit LCN2 expression in hepatocytes by promoting IκBζ degradation.[41] Here, we demonstrated that IL‐10 similarly suppresses LCN2 expression in GC cells by promoting IκBζ degradation. This evidence concerns the gene LCN2 and neoplasm.