Various tumor‐associated immune cells, including TAMs, cancer‐associated fibroblasts, mast cells, and neutrophils, play crucial roles in lymphangiogenesis.[16, 17, 18, 23] Furthermore, given that our results indicate LCN2 inhibits LN metastasis of GC via CCL5‐dependent macrophage activation, we hypothesized that TAMs may also be involved in LCN2‐dependent lymphangiogenesis. This evidence concerns the gene CCL5 and neoplasm.