Additionally, interleukin‐10 (IL‐10) derived from M2‐type TAMs suppresses IκBζ and its target gene, LCN2, in GC cells by promoting IκBζ degradation, thereby establishing an IL‐10/IκBζ/LCN2 positive‐feedback loop that sustains LCN2 suppression. Here, NFKBIZ is linked to gastric cancer.