It has been reported that Lgr5+ stem cells are the source of cancer stem cells for small intestinal adenoma and colorectal cancer (CRC).[21, 22] Thus, we determined expression levels of SNORD15B in CRC samples and found that SNORD15B was highly expressed in colon tumors (Figure S4F,G, Supporting Information), suggesting SNORD15B could be involved in the intestinal tumorigenesis. Here, LGR5 is linked to adenoma of small intestine.