Increased pathological aggregates: Treating neuroblastoma cells with LH increased their secretion of Aβ, due to an increased activity of BACE1, cleaving APP to its pathological form. As Aβ plaque formation can drive hyperphosphorylation of tau, this would further exacerbate AD pathologies (98). Experiments in OVX mice, guinea pigs, and human embryonic stem cells saw increases in APP when treated with LH (99). This evidence concerns the gene BACE1 and Alzheimer disease.