Two subsets of suppressive cancer‐associated fibroblasts were identified: Fibroblast activation protein‐α + cancer‐associated fibroblasts were found to promote the inflammatory response, immune exclusion, and CD8+ T cell exhaustion, while MYH11+ cancer‐associated fibroblasts created an immunosuppressive environment through recruitment of regulatory T cells, competing with the TLS‐mediated enhancement of the anti‐tumor response. The gene discussed is CD8A; the disease is cancer.