Indeed, TNFR superfamily member 8 (CD30)/CD153 signaling between CD153+ senescence‐associated T cells and CD30+ age‐associated B cells has been implicated in TLS expansion in aged murine kidneys after injury [59], and elevated circulating CD30 levels correlate with the presence of TLS and progression of IgA nephropathy [60]. The gene discussed is TNFSF8; the disease is IgA glomerulonephritis.