Many AD risk loci identified in European ancestry–‐focused GWASs are nominally associated with AD in Black Americans (APOE, ABCA7, BIN1, CASS4, CD33, CELF, CR1, BIN1, EPHA1, NME8),21, 22 Caribbean Hispanics (BIN1, CLU, Picalm),23 and East Asians (ABCA7, BIN1, CD33, CNTNAP2, PICALM, SORL1).22, 24, 25. Here, CASS4 is linked to Alzheimer disease.