The discovery GWAS of 9,111,557 variants and 21,736 participants adjusted for sex and APOE ε2 and ε4 dosages identified significant evidence of association between AAO of AD and seven known AD risk loci near APOE, BIN1, CASS4, CR1, HAVCR2, MS4A4A, and PICALM (λ = 1.03, LD score intercept = 1.04; Figure 2A, Table S1 in supporting information). Here, PICALM is linked to Alzheimer disease.