Many AD risk loci identified in European ancestry–‐focused GWASs are nominally associated with AD in Black Americans (APOE, ABCA7, BIN1, CASS4, CD33, CELF, CR1, BIN1, EPHA1, NME8),21, 22 Caribbean Hispanics (BIN1, CLU, Picalm),23 and East Asians (ABCA7, BIN1, CD33, CNTNAP2, PICALM, SORL1).22, 24, 25. This evidence concerns the gene APOE and Alzheimer disease.