The heterogenous signals at 5q33.3 and 17p11.2 do not implicate the AD risk gene at the same locus (Table 3), while their implicated genes have relatively modest links to AD biology: ADRA1B at 5q33.3 is differentially expressed in the AD brain and belongs to the vasculature AD domain, while LGALS9C at 17p11.2 is not associated with gene or protein expression in the AD brain. This evidence concerns the gene ADRA1B and Alzheimer disease.