In contrast, the two novel AAO GWAS signals at 11q13.1 and 18p11.21 implicate genes differentially expressed in the AD brain and involved in multiple AD biological domains: ESRRA is involved in structural stabilization, metal binding and homeostasis, and epigenetic AD domains, while RNMT is involved in the immune response and synapse AD domains. This evidence concerns the gene ESRRA and Alzheimer disease.