Our GWAS refines the known haplotypes associated with AD on 6p12.3 (CD2AP), 7q22.1 (pILRA), 11q14.2 (PICALM), and 20q13.31 (CASS4), with lead SNPs in moderate LD with the reported lead SNPs with attenuated p values in our study (Figures S9–S12 in supporting information). Here, PICALM is linked to Alzheimer disease.