Meta‐analysis of the discovery and replication GWAS identified 16 genome‐wide significant associations (λ = 1), including 14 known AD risk loci near APOE (APOC1), BIN1, CASS4, CD2AP, CR1, ECHDC3 (LOC105376412), EPHA1, HAVCR2 (ADRA1B), MS4A4A, MYO15A (FBXW10), PICALM, pILRA (NYAP1), SHARPIN, and UMAD1 while adding two new signals: chromosomes 11q13.1 near CATSPERZ and 18p11.21 near LDLRAD4 (Figure 2C, Table 2). The gene discussed is APOE; the disease is Alzheimer disease.