CCN3 and non-small cell lung carcinoma: However, our A549 WT cell lines, where either RANBP9 (Scorpin WT A549 iBP9) or RANBP10 (Scorpin WT A549 iBP10) are induced without the constitutive ablation of endogenous genes, provide a tool that avoids artifacts due to in vitro cell adaptation previously observed when manipulating CTLH proteins and better mimics human NSCLC tumors [2, 3] (Fig. 3).