Collectively, these results show that in NSCLC tumors, both the CTLHBP9 and the CTLHBP10 configurations are potentially involved in the regulation of biological processes such as multiple steps of RNA metabolism, but they also have distinct preferential associations with other biological processes such as cell proliferation, which was found to be strongly associated with the increased protein ratio RANBP9/RANBP10. The gene discussed is RANBP10; the disease is non-small cell lung carcinoma.