Thy1-SNCA transgenic mice overexpress the human wild-type SNCA under the murine Thy1 promoter (from P10) resulting in widespread SNCA accumulation in different brain areas including the midbrain, cerebellum, cortex, hippocampus, and medulla oblongata [43, 44], recapitulating key features of PD [43]. This evidence concerns the gene THY1 and Parkinson disease.